Pall’s Cadence BioSMB platform is the first disposable flow path, continuous multi-column chromatography solution that is fully scalable from the Process Development (PD) laboratory to GMP Manufacturing.

The BioSMB system is specifically designed to allow users to convert an existing batch process into a continuous chromatography step without changing the chromatographic sorbent, buffer system or product quality assays. BioSMB technology provides process consistency across all scales – development, clinical and full production – while making it practical to implement in flexible, multi-product facilities.

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Specifications

  • Width / Depth / Height

    47.2 / 28.7 / 22.8 in. (120 / 73 / 58 cm)

  • Weight

    375 lbs (170 kg)

  • Electrical Requirements

    115 VAC or 230 VAC

  • Air Supply

    At least 1 bar above process pressure

  • Capacity and Valve Cassette Specifications

    Up to 70 mL/min (1 mm cassette), Up to 700 mL/min (3 mm cassette)

  • Inlets

    Max 8

  • Outlets

    Max 8

  • Columns

    Max 16

  • Max Operating Pressure

    145 psi/10 bar

  • Pressure

    Linear up to 200 psi / 13.8 bar

  • UV-VIS

    Four UV-VIS sensors each with wavelengths in 200-850 nm range

  • pH

    Range of 0-14 accuracy of 0.1 pH unit (from 2-12)

  • Conductivity

    Range: 1 μS/cm – 200 mS/cm, Accuracy: 0.25 mS/cm (range 10 – 200 mS/cm) 3.0 μS/cm (range 0 – 100 μS/cm)

  • Maximum of 7 pumps

    Stepper motor direct drive dual piston pumps, PEEK fluid path, Automated piston seal wash, single capsule check valve

  • Accuracy

    Cadence BioSMB-PD-1: +/-5% at 1-50ml/min, Cadence BioSMB-PD-2: +/-5% at 1-8mL/min

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