Cadence Acoustic Separator (CAS) in conjunction with a polishing depth filter will continuously remove cells and cell debris from cell culture in a closed system, without the need for centrifugation or primary depth filtration.

The clarification process causes no significant increase in temperature or damage to cells or proteins, thereby maintaining high product quality within a smaller operating footprint.

Cadence Acoustic Separator is the first step in continuous processing.

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Features and benefits


Reduction in costs

Acoustic separation eliminates the need for primary depth filters and for centrifuge treatment bringing a substantial reduction in equipment and consumables costs.


Improved Product Quality

The cells and cell particulates are entrained by the acoustic wave enabling the target proteins to pass through unhindered. A robust ‘filter-less filter’ that will not clog or change performance over time.


Quick and Convenient Product Change

The single-use flow path enables simple rapid product deployment.


  • Cadence Acoustic Separator EU Version

    220 V / 50 Hz

  • Cadence Acoustic Separator US Version

    110 V / 60 Hz

  • RF Power Output

    0 - 100 W per channel

  • Maximum Power Consumption

    1.8 kW

  • Sonic Channels


  • Sonic Frequency

    1.9 - 2.2 MHz

  • Pump Flow Rate

    (L/S 16 tubing); 30 mL/min – 160 mL/min (L/S 14 tubing); 1 mL/min – 40 mL/min

  • Footprint (W/o Pump head)

    D 559 mm x W 546 mm x H 327 mm (22.0 in. D x 21.5 in. W x 12.875 in. H)

  • Footprint (W/Pump head)

    D 603 mm x W 546 mm x H 327 mm (23.75 in. D x 21.5 in. W x 12.875 in. H)

  • Pumps per Controller


  • Certification

    UL 61010-1, CAN/CSA C22.2# 61010-1 CENELEC EN 61010-1, CENELEC EN 61326-1, FCC 47CFR 15B clA

  • Weight

    18 kg (40 lb)

  • Configurations

    4 stages of CAC20, 1 stage of CAC50

  • Operating Temperature

    2 – 40 °C

  • Regulatory Information

    The Cadence Acoustic Separator meets national and international standards including UL 61010-1, CAN/CSA C22.2# 61010-1, CENELEC EN 61010- 1, CENELEC EN 61326-1, FCC 47CFR 15B clA

Download the full specification